H. K. Bdoyan, L. L. Danilova, V. E. Elbakyan, academician K. G. Karageuzyan

Characteristics of Structural and Methabolic Abnormalities of
Membrane-bound Phospholipids under the Conditions of Oxidative
Stress, Conditioning by Adrenaline Inducted Hyperglycemia

   The data obtained have shown that adrenaline induced hyperglycemia in white rats is accompanied by significant abnormalities in erythrocyte membranes of membrane-bound phospholipids. These changes are characterized by pronounced decrease of quantity of membrane-bound phosphatidylcholines, which was accompanied by the simultaneous increase of lysophosphatidylcholines level. Using on this background the super low concentrations (10-4M, 10-8M, 10-12M) of sodium thiosulfate is characterized by normalization of disorders mentioned with the exception of lysophospatidylcholines the high concentration of which remains unchanged. This fact has a special significance, which may be explained as the one mechanism of compensatory activity of the organism.