The purpose of the current study was in vitro the determination effect of different dosages of PRP-1 on some enzymes of carbohydrate - phosphate metabolism in rat bone marrow as well as the effect of stimulation of hypothalamic nuclei on above-mentioned enzymes. The dependency of different concentration of PRP-1 was revealed; decrease activity of alkaline phosphates (4500-3000 E) in addition to dosage 1g; slight increase of enzymatic activity of acid phosphates (1 and 1.5g) and sharp activation of inorganic pyrophosphates at PRP-1 concentration 0.5, 1.0, 3.0, and 5.0g have been noted. Especially there is of interest the 3-time increase of activity of acid phosphates compared to control in rats after stimulation. An Alkaline phosphate was mare stable to this physiological action. Inorganic phosphates revealed full resistance.